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Proteomics
Proteomics is the large-scale study of proteins, particularly their structures and functions. This term was coined to make an analogy with genomics, and is often viewed as the "next step", but proteomics is much more complicated than genomics. Most importantly, while the genome is a rather constant entity, the proteome is constantly changing through its biochemical interactions with the genome. One organism will have radically different protein expression in different parts of its body and in different stages of its life cycle.
The entirety of proteins in existence in an organism throughout its life cycle, or on a smaller scale the entirety of proteins found in a particular cell type under a particular type of stimulation, are referred to as the proteome of the organism or cell type respectively.
With completion of a rough draft of the human genome, many researchers are now looking at how genes and proteins interact to form other proteins.
A surprising finding of the Human Genome Project is that there are far fewer genes that code for proteins in the human genome than there are proteins in the human proteome (~33,000 genes vs ~200,000 proteins).
To catalogue all human proteins and ascertain their functions and interactions presents a daunting challenge for scientists. An international collaboration to achieve these goals is being co-ordinated by the Human Proteome Organisation (HUPO).
Key technologies used in proteomics research include mass spectrometry, x-ray crystallography, NMR and gel electrophoresis.
See also: glycomics
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AxCell Biosciences Corp.
Offers proprietary software, databases and services for charting protein pathway and signaling data, for drug-target discovery and agricultural industries. Subsidiary of Cytogen Corp. in Newtown, PA.
http://www.axcellbio.com/
Hybrigenics
Company inviting collaboration with biopharmaceutical companies on selected proteins, for mapping interactions, validating targets for drug screening for cancer, infectious and metabolic diseases, in Paris, France.
http://www.hybrigenics.fr/
Pride Proteomics ApS.
Based on expertise since 1979, exploiting 2D-gel electrophoresis, mass spectrometry, molecular biology and bioinformatics for identifying and characterizing markers of disease, target proteins in drug screening and diagnostic tools in Forskerparken, Odense, DK.
http://www.prideproteomics.com/
Amersham Biosciences
Flash presentation to promote the use of 2D-electrophoresis and mass spectrometry in the identification and charactarization of expressed proteins, using instruments manufactured by company based in Piscataway, NJ and Europe.
http://www5.amershambiosciences.com/APTRIX/upp00919.nsf/Content/proteomics_HomePage
Mobious Genomics
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http://www.mobious.com
CombiMatrix
CombiMatrix develops life science research products based on proprietary technologies in the areas of genomics and proteomics. CombiMatrix' products are designed to aid in the discovery and development of new drugs and diagnostics for human healthcare. The flexible and customizable technology is also suitable for animal and plant research, as well as industrial and biothreat applications.
http://www.combimatrix.com
BioMicro Systems
BioMicro a broad array of microfluidic biochip technologies to eliminate technological hurdles and processing bottlenecks currently limiting the development of new pharmaceutical compounds and the progress of genomics, proteomics and diagnostics research.
http://www.biomicro.com
Medical ProteoScope
MPS's integrated technology platform is being used to discover proteins for biomarkers, therapeutic markers and drug targets which correlate well with specific clinical parameters of diseases.
http://www.medicalproteoscope.com/toppage/top_e.shtml
ViaLogy
Using its Quantum Resonance Interferometry technology, Vialogy provides quantum improvements in increased detection sensitivity of DNA microarrays, Protein Chips and other detection instruments by four orders of magnitude.
http://www.vialogy.com
Arcturus Bioscience
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PRS - Proteomic Research Services
PRS is a company dedicated to providing quality service in protein separations and biological mass spectrometry.
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Biocept
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Correlogic Systems
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Syn X Pharma
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Cryptome Pharmaceuticals
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Matritech, Inc.
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ProMetic Life Sciences
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SurroMed
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http://www.surromed.com
TECAN
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Biospect
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Eksigent
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Kinexus
Kinexus is harnessing the powerful synergies of genomics, proteomics and bioinformatics to understand cell signalling for the advancement of drug discovery, disease diagnosis, and global biomedical research.
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ACE BioSciences
ACE is based on a broad biotechnology platform integrating infectious disease biology with analytical protein chemistry and bioinformatics with a core competence in protein interaction technology.
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Eclipse Diagnostics
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Prolexys Pharmaceuticals
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Proteome Factory AG.
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Northern Lights Proteomics, LLC
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Proteome Systems Ltd
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AmProx
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Agilix
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ProteinOne
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Target Discovery
A discovery biology company with six revolutionary platform technologies under development spanning enabling technologies in expressional proteomics, interactional proteomics, metabolomics and systems biology.
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Proteos
Proteos is a company which offers its customers production of proteins and peptides, and input ranging from consultation on strategies covering all aspects of protein production and purification to service or research in providing crude, or pure proteins and peptides.
http://www.proteos.net
Tienta Sciences
Tienta focuses on the development of proprietary substrates and their applications for Raman, Infrared, and Mass Spectrometry to revolutionize biomedical research and medicine.
http://www.tientasciences.com/
Panacea Pharmaceuticals
Panacea is an emerging biopharmaceutical company focused on utilizing functional genomics and proteomics to develop therapeutic agents and diagnostic tests for diseases with substantial unmet clinical need.
http://www.panaceapharma.com
GeneProt
GeneProt is a life science company using the very latest developments in protein technologies to improve the quality and speed of the drug discovery and development process.
http://www.geneprot.com
Definiens
Definiens has developed Proteomweaver designed to overcome operational gap and to accelerate the R&D process in proteomics research by offering automation, throughput, reliability and accuracy at a level unmatched by any other solution in the field.
http://www.definiens.com
Protagen
Protagen is applying latest proteomics technologies to services and product development for the life science industries.
http://www.protagen.de
HTS Biosystems
HTS Biosystems is creating comprehensive and integrated systems and solutions that enhance and expedite the discovery, validation, and screening of target proteins.
http://www.htsbiosystems.com
MelTec
MelTec is a pioneer in topological proteomics optimising the drug discovery process in the post-genomic era. MelTec represents the only company with a proprietary technology capable of performing completely automated proteomics characterization at the single cell level, for an unlimited number of proteins.
http://www.meltec.de
Ionalytics
Ionalytics designs and manufactures the Ionalytics Selectra. The Selectra, which can be attached to existing or new mass spectrometers, is currently being used within drug discovery markets in both pharmaceutical and proteomics applications.
http://www.ionalytics.com
HK Pharmaceuticals, Inc.
Drug company focusing on high definition protein discovery and characterization technology, in design of new medicines and optimizing existing drugs. Corporate aims, time-line, and contacts for careers in San Diego, California.
http://www.hkpharmaceuticals.com/
Inpharmatica
Offers platform, genomic and proteomic database for simultaneous bioinformatics, chemogenomics, disease indication and pharmacology research. Includes investor relationships, corporate news, recruitment in London, UK.
http://www.inpharmatica.co.uk/
ProteoSys AG.
Company concentrating on multidimensional proteome analysis for target identification and validation. Includes technology platform, diagnostic marker for Alzheimer, prostate and epithelial cancers, and careers at Mainz, Germany.
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Protein Expert SA.
Contract manufacturing organization, offering custom research and technology platform in recombinant protein production, for academic laboratories, pharmaceutical, biotech and food industries, in Grenoble, France.
http://www.proteinexpert.com/
Procognia Ltd.
Offers array-based proteomic solutions for glycan analysis or glycoproteins and protein function assays from Maidenhead, UK.
http://www.procognia.com/
Proteomics Applications Information
Promotion of the ProteomeX workstation, through a series of European seminars, organized by Thermo Finnigan.
http://www.thermo.com/proteomics/
Eprogen
ProteoSep gel-free technology using LC-MS and other characterization techniques, for mapping intact proteins retained in the liquid phase for subsequent post translational modifications. Offers licensing or contract services in Darien, Illinois.
http://www.eprogen.com/
SomaLogic, Inc.
Technology and services based on photoaptamer array applications for the life sciences research and industry, from Boulder, Colorado.
http://www.somalogic.com/
Vitateq
Looking for medicinal solutions to help treat infertility disorders, cardio-vascular diseases and neurodegenerative ailments. Includes current research, news releases, and profile of company in Innsbruck, Austria.
http://www.vitateq.com/
BD Biosciences: Proteomics
BD Biosciences provides integrated, high-value products and services for genomics, proteomics, drug discovery & development, oncology, and immune function.
http://www.bdbiosciences.com/proteomics/
DataCentric Automation
DataCentric Automation specializes in the design and delivery of high-tech systems for the laboratory and drug discovery markets, especially in the fields of protein crystallography, proteomics, and genomics.
http://www.dcacorp.com
Sidec Technologies AB
The company provides solutions for three dimensional imaging of biomolecules-a structure function discovery company with focuses on characterization of proteins and protein interactions for the pharmaceutical industry.
http://www.sidectech.com
Molecular Staging
The MSI approach to proteomics with a systematic, highly parallel approach that enables researchers to study the expression of numerous proteins simultaneously. The MSI chip-based proteomics discovery platform offers researchers a powerful new way to identify new individual and multiplexed sets of biomarkers.
http://www.molecularstaging.com
NextGen Sciences
NextGen is a provider of integrated solutions for protein research. The company’s advanced technologies fully automate established, complex research techniques, improving results and accelerating discovery.
http://www.nextgensciences.com
ActivX Biosciences
ActivX is applying proprietary chemical technologies and high-throughput protein analysis. By focusing specifically on functional proteins, ActivX technology addresses disease mechanisms directly.
http://www.activx.com
Protea Biosciences
Protea providea an integrated protein biomarker identification and characterization capability by linking our proprietary solution-based LC MS/MS protein identification technology with extensive archives of highly characterized biological samples and biological assays.
http://www.proteabio.com
TransTech Pharma
TransTech's TTP Translational Technology platform utilizes and translates genomic and proteomic data into safe and effective small molecule therapeutics in high throughput fashion, bypassing most of the classical requirements and bottlenecks in drug discovery.
http://www.ttpharma.com
Calibrant Biosystems
Calibrant Biosystems provides next-generation instruments for advanced proteomics research by using fully integrated multidimensional capillary and microfluidic technologies
http://www.calibrant.com/
FFE-Weber
FFEWeber GmbH develop and advance Free Flow Electrophoresis (FFE) and its application in research of biopolymers and bioparticles, with the focus in the field of proteomics research.
http://www.f-f-e.com/
Power3 Medical Products
Power3 Medical Products is a biotechnology company engaged in the discovery of protein footprints, pathways, and mechanisms of diseases.
http://www.power3medical.com/
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